Ototoxicity refers to a condition in which drugs or chemicals poison the ear. It affects the inner ear or vestibulocochlear nerve. Since the inner ear and the nerve going to the brain from these structures provide information about sound and balance, both of these functions may be affected.
Causes of Ototoxicity
Many drugs have the potential of causing ototoxicity. They include aminogylcoside antibiotics, anti-cancer drugs, diuretics, quinines and aspirin containing drugs. In addition, environmental chemicals, such as xylene, toluene and trichloroethylene can lead to ototoxicity. The areas which are damaged or destroyed from ototoxicity include the vestibulocochlear nerves and the hair cells of the inner ear. The hair cells provide a very important part of the sensory mechanism of hearing and balance.
Signs and Symptoms of Ototoxicity
They symptoms of ototoxicity range from mild hearing loss and imbalance to deafness, tinnitus and severe vertigo and dizziness. There may be an unstable gait. Nausea and vomiting may occur
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Medical Content Last Updated on 07/12/2008
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