Symptoms of PLATELET DYSFUNCTION

Platelet disorders all interfere with primary and secondary hemostasis, or blood-clotting. Consequently, there is usually a history of excessive or easy bruising. In women, there may be excessive menstrual bleeding or frequent menstrual bleeding. Surgical procedures or injuries are often accompanied by unexpected heavy blood loss. In disorders where the platelets are isolated by the spleen, a mass may develop in the left upper abdomen. Sometimes, platelet disorders can occur in combination with viral infections, such as infectious mononucleosis, toxoplasmosis, viral hepatitis or HIV/AIDS. The symptoms that occur are then usually part of the disease process of these individual clinical entities.