Symptoms of SCHULLER-CHRISTIAN SYNDROME

Symptoms or Hand-Schuller-Christian disease are frequently the result of abnormal deposits of Histiocyte. These deposits lead to weakened bones. When the weight bearing bones, such as the legs or spine are involved, they may fracture spontaneously or after minimal trauma. There is often systemic involvement that can lead to generalized symptoms and ill feeling. Not surprisingly, with a disease that affects so many systems and organs, Histiocytosis may be deadly. Adults may develop cough, shortness of breath and chest pain. Fever, weight loss and rash may occur. Due to involvement of the pituitary gland, hormones that regulate urine output may become affected. This can lead to excessive urination and increased thirst. Pain in one or may bones may occur. Infants may demonstrate a failure to thrive. Development of children can be retarded with short stature and delayed puberty. In addition to the symptoms mentioned above for adults, children may have abdominal pain, vomiting and yellowing of the skin. Headaches, seizures, dizziness and mental deterioration may occur. The eyes may appear swollen or prominent. There may be enlargement of the glands in the neck, armpit or groin. Bone pain may be seen as well as limping.