Symptoms of MYELOFIBROSIS

The symptoms are in large part a reflection of decreased production of certain blood cells which come from the bone marrow. Weakness, fatigue and shortness of breath are all a reflection of anemia, or decreased number of red cells. The individual may also appear pale and have loss of appetite. Bleeding and easy bruising is due to inadequate numbers of blood clotting cells. These platelets are essential to allow for the normal control of bleeding that can occur after an injury. Fever and night sweats are thought to be a manifestation of the decreased number of white cells. Jaundice, yellowing of the skin and eyes, occurs secondary to damage to the liver. Swelling and tenderness of the abdomen, usually in the left or right upper abdomen, occurs from enlargement of the liver and spleen. This often occurs as these areas become sites of blood cell production. Joint pain and back pain may, also, occur.